Antibacterial Drugs

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Salvica-of Tablets
Cefixime…… 200 mg….. β lactam antibiotics (Third generation cephalosporin antibiotic)
Ofloxacin IP…200 mg…. Second-generation fluoroquinolone
 
Clinical Pharmacology
Cefixime:
Pharmacokinetic Actions
Cefixime is absorbed after oral administration and has a bioavailability of about 40% to 50%.
Its protein binding is approximately 60% with an average half-life of 3 to 4 hours.
The distribution volume is 3.5 l/kg and total clearance is approximately 15 l/h. The half-life in plasma is 10-1 2 hours and gives a 24 hour effect after dosing once daily. Its excretion is through renal and biliary route.
Ofloxacin:
Pharmacokinetic Actions
It is absorbed after oral administration and has a bioavailability of about 50 to 70%.
Its protein binding is approximately 60% wEth an average half-life of 0.75 to 1 hours.
Its excretion is through renal route.
Mechanism Of Action:
Cefixime: It is bactericidal beta-lactam antibiotic (such as penicillins). Cefixime disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan.
Ofloxacin: Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, which is an enzyme necessary to separate replicated DNA, thereby inhibiting cell division. The fluoroquinolones interfere with DNA replication by inhibiting an enzyme complex called DNA gyrase. This can also affect mammalian cell replication.
Recent studies have demonstrated a correlation between mammalian cell cytotoxicity of the quinolones and the induction of micronuclei. As such some fluoroquinolones may cause injury tothe chromosome of eukaryotic cells.

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Our clients have been a huge inspiration behind the wide array of Ofloxacin Tablets offered by us. We follow the international standards of quality while testing these products. As per the needs and requirements of our clients, we can also customize the packaging quantities of these products.
Features:

Quick response

Precise composition

Longer shelf life

Zero side effect

High purity

Uses:

This medication is used to treat a variety of bacterial infection

Ofloxacin belongs to a class of drugs called quinolone

It works by stopping the growth of bacteria

This treats only bacterial infection

Specification:

Composition: Ofloxacin

Additional Information:

• Item Code: Salof-200-Tablets

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Description:
Salof-MS has in vitro activity against a broad spectrum of gram-positive and gram-negative aerobic and anaerobic bacteria. Ofloxacin is thought to exert a bactericidal effect on susceptible microorganisms by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication, transcription, and repair of bacterial DNA.Ofloxacin has been shown to be active against most strains of the following microorganisms both in vitro and in specific clinical infections.
Gram-positive Aerobes:
Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes.
Gram-negative Aerobes:
Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Proteus mirabilis, Pseudomonas aeruginosa
Other:
Chlamydia trachomatis.Ornidazole is a 5-nitroimidazole derivative with actions similar to Metronidazole and Tinidazole and is used in the treatment of susceptible Protozoal Infections and also in Anaerobic Bacterial Infections.It is effective against Protozoa including Entamoeba histolytica, Giardia lambia and Trichomonas spp and Bacteria such as Bacteriodes spp., Anaerobic cocci, Fusobacterium spp., Clostridum spp., and Gardenerlla vaginalis. It acts by damage of DNA strands or inhibition of their synthesis.Both Ofloxacin and Ornidazole are almost completely absorbed from the small intestine when administered orally both having almost 100% bioavailability. Subsequent plasma concentrations of Ofloxacin are obtained in 1-2 hours after oral administration. Peak plasma concentrations of Ornidazole are obtained within 2 hours of administration.The plasma elimination of Ornidazole is 12 to 15 hours and less than 15% is bound to plasma proteins. It is widely distributed in body tissues and fluids. Ornidazole is metabolised in the liver and is excreted in the urine mainly as metabolites and conjugates and to a lesser extent in the faces.
Indications:
Salof-OZ is indicated for the treatment of a wide variety of infections caused by susceptible gram-positive and gram-negative organisms along with anaerobes and protozoa. Gynaecological infections including prophylaxis in gynaecological surgeries. Surgical prophylaxis and surgical wound infections. Respiratory tract infections like lung abscess, aspiration pneumonia, empyema and bronchiectasis. ENT infections like chronic sinusitis, chronic suppurative otitis media, cholesteatoma and mastoiditis. Orofacial and dental infections.Dermatological infections like cellulitis, breast and other cutaneous abscesses, angrene, diabetic and decubitus ulcers.Intra-abdominal infections and diarrhoeas of mixed bacterial and protozoal origin.
Dosage:
The usual adult dose is one tablet of Salof-OZ twice a day. The doses may be increased in severe infections. The duration of treatment depends upon the type and severity of infection.
Contraindications:
Hypersensitivity to the quinolone group or the nitroimidazole group of compounds and in those patients with a history of blood dyscrasias.
Other Details:
Each 5 ml contain
Ofloxacin 50mg
Ornidazole 125 mg

Additional Information:

• Item Code: Salof-OZ_Susp

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Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.

A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.

LD50=5450 mg/kg (orally in mice)

DISCLAMOUR
The information given above is not meant for diagnosing a disease or its treatment. This information is for our pharmaceutical sales persons only. 

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each film coated tablet contains:

cefpodoxime proxetil ip 200 mg

ofloxacin ip 200 mg

cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class. Cefpodoxime it is active against most gram positive and gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis.

ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.

indications:

● acute otitis media

● pharyngitis and/or tonsillitis

● community-acquired pneumonia

● acute bacterial exacerbation of chronic bronchitis

● acute, uncomplicated urethral and cervical gonorrhea

● acute, uncomplicated ano-rectal infections in women

● uncomplicated skin and skin structure infections

● acute maxillary sinusitis

● uncomplicated urinary tract infections (cystitis)

rationale of combination:

product description:

● unique dual mode of action

● ofloxacin-prevents nucleic acid synthesis

● cefpodoxime-inhibits cell wall synthesis

● acts synergetically

• gives better patient compliance.

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