Antibacterial Drugs

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Our clients have been a huge inspiration behind the wide array of Ofloxacin Tablets offered by us. We follow the international standards of quality while testing these products. As per the needs and requirements of our clients, we can also customize the packaging quantities of these products.
Features:

Quick response

Precise composition

Longer shelf life

Zero side effect

High purity

Uses:

This medication is used to treat a variety of bacterial infection

Ofloxacin belongs to a class of drugs called quinolone

It works by stopping the growth of bacteria

This treats only bacterial infection

Specification:

Composition: Ofloxacin

Additional Information:

• Item Code: Salof-200-Tablets

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Salvica-of Tablets
Cefixime…… 200 mg….. β lactam antibiotics (Third generation cephalosporin antibiotic)
Ofloxacin IP…200 mg…. Second-generation fluoroquinolone
 
Clinical Pharmacology
Cefixime:
Pharmacokinetic Actions
Cefixime is absorbed after oral administration and has a bioavailability of about 40% to 50%.
Its protein binding is approximately 60% with an average half-life of 3 to 4 hours.
The distribution volume is 3.5 l/kg and total clearance is approximately 15 l/h. The half-life in plasma is 10-1 2 hours and gives a 24 hour effect after dosing once daily. Its excretion is through renal and biliary route.
Ofloxacin:
Pharmacokinetic Actions
It is absorbed after oral administration and has a bioavailability of about 50 to 70%.
Its protein binding is approximately 60% wEth an average half-life of 0.75 to 1 hours.
Its excretion is through renal route.
Mechanism Of Action:
Cefixime: It is bactericidal beta-lactam antibiotic (such as penicillins). Cefixime disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan.
Ofloxacin: Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, which is an enzyme necessary to separate replicated DNA, thereby inhibiting cell division. The fluoroquinolones interfere with DNA replication by inhibiting an enzyme complex called DNA gyrase. This can also affect mammalian cell replication.
Recent studies have demonstrated a correlation between mammalian cell cytotoxicity of the quinolones and the induction of micronuclei. As such some fluoroquinolones may cause injury tothe chromosome of eukaryotic cells.

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each film coated tablet contains:

cefpodoxime proxetil ip 200 mg

ofloxacin ip 200 mg

cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class. Cefpodoxime it is active against most gram positive and gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis.

ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.

indications:

● acute otitis media

● pharyngitis and/or tonsillitis

● community-acquired pneumonia

● acute bacterial exacerbation of chronic bronchitis

● acute, uncomplicated urethral and cervical gonorrhea

● acute, uncomplicated ano-rectal infections in women

● uncomplicated skin and skin structure infections

● acute maxillary sinusitis

● uncomplicated urinary tract infections (cystitis)

rationale of combination:

product description:

● unique dual mode of action

● ofloxacin-prevents nucleic acid synthesis

● cefpodoxime-inhibits cell wall synthesis

● acts synergetically

• gives better patient compliance.

Approx. Rs 230 / StripGet Latest Price

Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.

A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.

LD50=5450 mg/kg (orally in mice)

DISCLAMOUR
The information given above is not meant for diagnosing a disease or its treatment. This information is for our pharmaceutical sales persons only.