Pain Killers

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• Paracetamol (Acetaminophen) is a non-steroidal anti-inflammatory drug (NSAID) in a class of medications called analgesics and antipyretics. Paracetamol Tablets are used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations, and to reduce fever. Paracetamol may also be used to relieve the pain of osteoarthritis. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.

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Fenasal-T4/T8 Tab

Each Film Coated Tablet Contains:

Aceclofenac  IP          100 mg

Thiocholchicoside      4/8 mg

Aceclofenac is an orally administered phenylacetic acid derivative with effects on a variety of inflammatory mediators. It is from the class of non-steroidal anti-inflammatory drug (NSAID), related to diclofenac. Through its analgesic and anti-inflammatory properties, aceclofenac provides symptomatic relief in a variety of painful conditions.

Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside with a relaxant effect on skeletal muscle, has been found to displace both [3H]gamma-amino butyric acid ([3H]GABA) and [3H]strychnine binding, suggesting an interaction with both GABA and strychnine-sensitive glycine receptors.

Indications:
Anti-Inflammatory, Analgesic, Neck and Shoulder Pain .

Rationale of Combination:

Product Description:
Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside and is a muscle relaxant agent with anti-inflammatory and analgesic actions, also is used topically for the treatment of muscular spasms and for rheumatologic, orthopedic, and traumatologic disorders and has been found to displace both [3H] gamma-amino butyric acid ([3H] GABA) and [3H] strychnine binding, suggesting an interaction with both GABA and strychnine-sensitive glycine receptors. Aceclofenac belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs) and of phenyl acetic acid derivative with effects on a variety of inflammatory mediators. It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause pain, swelling and inflammation. Combination of proven NSAID Aceclofenac with an effective non sedating Muscle Relaxant Thiocolchicoside to treat painful muscle spasm.

Additional Information:

• Pay Mode Terms: T/T (Bank Transfer)

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Therapeutic Indications Usage

FENASAL-PT4 is indicated for:

•Trauma Surgery: In sports injuries, sprains, laceration, fractures, dislocation and osteoarthritis etc.

•Surgery: To reduce post-operative edema at injection sites, internal tissue edema and inflammation

caused at post-operative handling.

•Plastic Surgery: For diminishing post-operative edema, restoring micro-circulation at the site of graft

and minimizing risk of graft rejection along with reduction in pain.

•Infections: Facilitating mucolysis in sinuses, ear cavities and coupled with anti-inflammatory activity in

upper respiratory tract affections helps in faster resolution, better antimicrobial availability in infected

tissues and faster cures.

•Dermatology: Particularly useful in acutely painful inflamed dermatoses.

•Dentistry: Helps better control over dental infections and inflammation.

•Obstetrics Gynecology: The anti-inflammatory and anti-edema activity helps in resolution of post-

partum hematomas, breast engorgements and pregnancy-related thrombophlebitis.

Contraindications

FENASAL-PT4 is contraindicated in patients with hypersensitivity to any of the ingredients, in those known to have bronchospasm or acute rhinitis or urticaria with aspirin or similar agents, presence of active or suspected peptic ulcer, gastrointestinal or other active bleeding, bleeding disorders, severe heart or kidney or liver failure. It is not advocated in children, and during pregnancy and lactation.

Precautions

FENASAL-PT4 should be administered with caution in patients with acid-peptic disease, inflammatory bowel disease, impaired renal or liver functions, blood dyscrasias, SLE, porphyria, hematopoietic and coagulation disorders, and in patients with hypersensitivity to aspirin or other NSAIDs.

Warnings

Aceclofenac (in FENASAL-PT4) is to be advocated with due caution in those on diuretics, or otherwise at risk of hypovolemia. It should be used in pregnant women and nursing mothers only if absolutely required. Data on safety and efficacy of aceclofenac (in FENASAL-PT4) in children is not adequate. In those receiving long-term FENASAL-PT4, periodical monitoring of renal and hepatic functions and blood counts is necessary.

Aceclofenac (in FENASAL-PT4) should be co-administered with caution along with oral thrombolytics, diuretics, cyclosporine, tacrolimus, phenytoin, digoxin, cimetidine, tolbutamide, phenylbutazone, amiodarone, miconazole, sulfaphenazole, methotrexate, lithium, and highly protein-bound drugs. Since serratiopeptidase may increase the action of anticoagulative drugs, these must be coadministered with caution with FENASAL-PT4. Intake of alcohol with FENASAL-PT4 must be with due precaution.

Recommended Dosage Administration

ADULTS: I FENASAL-PT4 Tab daily 1-2 hours after meals, or as prescribed.

Additional Information:

• Pay Mode Terms: T/T (Bank Transfer)
• Port of Dispatch: Chandigarh

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Each Film Coated Tablet Contains:

Composition:

Diclofenac Potassium......................50 mg

Paracetamol.................................325 mg

Serratiopeptidase............................10 mg

Diclofenac Potassium is a nonsteroidal anti-inflammatory drug (NSAIDs) that exhibits anti- inflammatory, analgesic, and antipyretic activities.

Paracetamol, also known as Acetaminophen, is commonly used for its analgesic and antipyretic effects. Serratiopeptidase is a proteolytic enzyme (protease) produced by Enterobacterium Serratia sp. E-15 used in the prevention of pain and swelling.

Indications and Usage:

Diclofenac Potassium:

For treatment of primary dysmenorrhea.

For relief of mild to moderate pain.

For relief of the signs and symptoms of osteoarthritis.

For relief of the signs and symptoms of rheumatoid arthritis.

Paracetamol:

For mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains).

To reduce fever.

Serratiopeptidase:

Anti-inflammatory properties.

Post-traumatic swelling.

Fibrocystic breast disease.

Bronchitis.

Rationale of Combination:

Product Description:

Diclofenac potassium is used as an anti-inflammatory agent to pacify mild to moderate pain and inflammation. Common conditions associated with pain and inflammation includes arthritis, trauma, surgery and fibermyalgia whereas paracetamol is used for temporary relief of fever, minor aches, and pains. Additionally, serratiopeptidase helps to reduce fluid retention in affected areas, which contributes to proper drainage and a quicker recovery.

Pharmacology:

Diclofenac Potassium:

Diclofenac is an acetic acid non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac inhibits the production of prostaglandins by inhibiting COX-1 and COX-2 pathways thereby exhibiting anti- inflammatory effects.

Absorption: Well absorbed following oral administration.

Distribution: widely distributed in animals. Plasma protein binding exhibited is >99%.

Elimination: Hepatic metabolism leads to elimination through urine.

Serratiopeptidase:

Serratiopeptidase is an enzyme isolated from a non-pathogenic bacteria called Enterobacteria Serratia E15. Serratiopeptidase has powerful anti-inflammatory properties and is particularly useful for post-traumatic swelling, fibrocystic breast disease and bronchitis. It is able to digest dead tissue, blood clots, cysts, and arterial plaques.

Absorption: On oral administration, serratiopeptidase is absorbed in GI tract.

Distribution: Distributed throughout the body tissues, unchanged via systemic circulation. It reaches in higher concentration in inflamed tissues. Serratiopeptidase levels in inflammatory exudates rises gradually with decline in blood levels indicating that serratiopeptidase is quite rapidly transferred to the site of inflammation.

Paracetamol:

Paracetamol is a widely used analgesic and antipyretic agent.

Adverse Effects:

Skin rash

Diarrhea

Gastrointestinal disturbance/Abdominal pain (or stomach pain)/Heartburn or

Nose bleed

Nausea

Allergic reactions

Dizziness

Contraindications:

Contraindicated in patients with severe ulcer gastrointestinal bleeding, and hypersensitivity. Diclofenac sodium and Serratiopeptidase is contraindicated in patients with asthma, renal or hepatic disorders, hypertension, porphyria, peri- operative pain in CABG surgery patients and bleeding disorders.

Additional Information:

• Pay Mode Terms: T/T (Bank Transfer)

Approx. Rs 98 / UnitGet Latest Price

We are engaged in offering a quality-assured range of Trypsin & Chymotrypsin Tablets, fabricated using supreme quality raw material, procured from reliable sources of the industry. Our professionals test these products in tandem with international quality standards by making use of latest technology and advanced tools and equipment. Moreover, we make sure to offer these products in varied quantities in order to meet the exact requirements of the clients.

Features:

• Quick response
• Precise composition
• Longer shelf life
• Zero side effects
• High purity
• High effectiveness

Uses:

• Tab Chysin Forte is a Proteolytic Enzyme and is used to reduce redness and swelling associated with pockets of infection (abscesses), ulcers, surgery, or traumatic injuries
• It helps loosen phlegm in asthma, bronchitis, lung diseases, and sinus infections

Details:

• Composition: Trypsin & chymotrypsin

Additional Information:

• Item Code: Tab-Chysin-Forte

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Chysin-BR Tablet

• each enteric coated tablet contains
• trypsin bp 48 mg
• bromelain 90 mg
• rutoside trihydrate bp 100 mg
• trypsin and bromelain belong to the class of
• naturally occuring systemic enzymes and
• rutoside trihydrate is a phytonutrient.

indications
chysin-br tablets can be used in the treatment of following conditions:

post-operative pain.

edema and inflammation in contusions, lacerations, cuts, sinusitis, otitis, externa, pid (pelvic inflammatory disease), tooth extraction, cellulitis, abscess, sport injuries, sprains and surgery.

• painful osteoarthritis, rheumatoid arthritis, spondylopathies, tendonitis, polymyositis, dermatomyositis and gout.
• pain management of kidney stones and gallstones, chronic pain in cancer, post-traumatic pain, dysmenorrhea and acute migraines.
• temporary relief from aches, pains and muscle soreness due to everyday activity.

dosage:

• one chysin-br tablet three times a day or as directed by physician.

mechanism of action

trypsin and bromelain are proteolytic enzymes. they break peptide bond inside protein molecules. bromelain exerts anti-inflammatory activity by affecting prostaglandin synthesis. rutoside is a glycoside and has antioxidant effect. it increases the strength of the walls of the blood capillaries and regulates their permeability.

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Additional Information:

• Pay Mode Terms: T/T (Bank Transfer)
• Port of Dispatch: CHANDIGARH

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Etonox-600mg ER Tablet

Each tablet contains:

Etodolac 600 mg (SR)

This drug is used to treat short-term pain, as well as long-term joint pain and inflammation in various types of arthritis.

Etodolac is approved to treat:

· osteoarthritis (immediate and extended-release forms)

· rheumatoid arthritis (immediate and extended-release forms)

· juvenile rheumatoid arthritis (extended-release form)

· short-term pain (immediate release form-We have Etonox-P)

How it works

This medication belongs to a Non Steroidal Anti-inflammatory Drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever. It acts anti-inflammatory by lowering levels of COX-2 prostaglandin, a hormone-like substance that usually causes inflammation.

Etodolac side effects

The common side effects that occur with etodolac include:

· nausea, vomiting

· diarrhoea or constipation

· stomach pain

· dizziness

· headache

Serious side effects

If patient experiences any of these side effects, they should report it to doctor right away.

o chest pain, shortness of breath

o weakness on one side of your body

o slurred speech

o yellowing of your skin or the whites of your eyes

o flu-like symptoms, such as body aches, headaches, fever, nausea, and vomiting

o tiredness

o pain in the upper part of your stomach

o itching

o reddening, blistering, or peeling skin

Safety for use for pregnant or brest feeding women is not established

For seniors: People aged 65 years or older should use caution when taking this medication. Your kidneys may not work as well, which could make it harder to remove this drug from your body. This increases your risk of side effects. Your doctor may monitor your kidneys regularly.

For children: It isn’t known if the immediate-release form of this medication is safe or effective in people younger than 18 years. It isn’t known if the extended-release form of this medication is safe or effective in people younger than 6 years.

Dosage for people younger than 18 years hasn’t been established.

Disclaimer: This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you. This information is only a guide line for marketing professionals and is insufficient for Medical Practioners to prescribe.

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FENASAL-SP

Composition

Each tablet of FENASAL-SP contains:

Aceclofenac. . .100 mg

Serratiopeptidase… 15 mg

Paracetamol. . .500 mg

Therapeutic Indications Usage

FENASAL-SP is indicated for:

•Trauma Surgery: In sports injuries, sprains, laceration, fractures, dislocation and osteoarthritis etc.

•Surgery: To reduce post-operative edema at injection sites, internal tissue edema and inflammation

caused at post-operative handling.

•Plastic Surgery: For diminishing post-operative edema, restoring micro-circulation at the site of graft

and minimizing risk of graft rejection along with reduction in pain.

•Infections: Facilitating mucolysis in sinuses, ear cavities and coupled with anti-inflammatory activity in

upper respiratory tract affections helps in faster resolution, better antimicrobial availability in infected

tissues and faster cures.

•Dermatology: Particularly useful in acutely painful inflamed dermatoses.

•Dentistry: Helps better control over dental infections and inflammation.

•Obstetrics Gynecology: The anti-inflammatory and anti-edema activity helps in resolution of post-

partum hematomas, breast engorgements and pregnancy-related thrombophlebitis.

Contraindications

FENASAL-SP is contraindicated in patients with hypersensitivity to any of the ingredients, in those known to have bronchospasm or acute rhinitis or urticaria with aspirin or similar agents, presence of active or suspected peptic ulcer, gastrointestinal or other active bleeding, bleeding disorders, severe heart or kidney or liver failure. It is not advocated in children, and during pregnancy and lactation.

Precautions

FENASAL-SP should be administered with caution in patients with acid-peptic disease, inflammatory bowel disease, impaired renal or liver functions, blood dyscrasias, SLE, porphyria, hematopoietic and coagulation disorders, and in patients with hypersensitivity to aspirin or other NSAIDs.

Warnings

Aceclofenac (in FENASAL-SP) is to be advocated with due caution in those on diuretics, or otherwise at risk of hypovolemia. It should be used in pregnant women and nursing mothers only if absolutely required. Data on safety and efficacy of aceclofenac (in FENASAL-SP) in children is not adequate. In those receiving long-term FENASAL-SP, periodical monitoring of renal and hepatic functions and blood counts is necessary.

Aceclofenac (in FENASAL-SP) should be co-administered with caution along with oral thrombolytics, diuretics, cyclosporine, tacrolimus, phenytoin, digoxin, cimetidine, tolbutamide, phenylbutazone, amiodarone, miconazole, sulfaphenazole, methotrexate, lithium, and highly protein-bound drugs. Since serratiopeptidase may increase the action of anticoagulative drugs, these must be coadministered with caution with FENASAL-SP. Intake of alcohol with FENASAL-SP must be with due precaution.

Recommended Dosage Administration

ADULTS: I FENASAL-SP Tab daily 1-2 hours after meals, or as prescribed.

Presentations

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Each Uncoated Tablet Contains:

• Diclofenac Sodium BP 50 mg
• Paracetamol IP 325 mg
• Chlorzoxazone USP 250 mg

It is a pain reliever prescribed to treat a wide variety of conditions. The combination of medications makes it useful for relieving inflammation, relaxing muscle, and reducing both fevers and pains. It is commonly used to patients suffering from severe headaches, arthritis, swelling or skeletal muscle injuries.

INDICATIONS AND USAGE:

• Soft tissue injuries with spasm and inflammation,
• Neck / shoulder / back pain,
• Tendonitis / tenosynovitis / bursitis
• Musculoskeletal disorders

RATIONALE OF COMBINATION:

Product Description: Given the multiple pathways involved in body's perception of pain, a combination therapy is well suited for pain management.

Diclofenac acts by attenuation of peripheral prostaglandin synthesis(primarily) and has marked anti-inflammatory effect

Paracetamol acts centrally and inhibits brain prostaglandin synthesis which may partly account for its well documented activity to reduce fever and to induce analgesia.

Chlorzoxazone being a centrally acting muscle relaxant, relieves muscular spasms. The combination exerts a better pain control due to action on different pathways of pain.

PHARMACOLOGY:

Diclofenac is a NSAID with anti­inflammatory, analgesic and antipyretic properties. It is rapidly and almost completely absorbed when administered as an oral dose. Food does not have a significant effect on the extent of oral absorption. At therapeutic concentrations it is more than 99% bound to plasma proteins. Diclofenac and/or its metabolites are rapidly and preferentially taken up and retained in inflamed tissues. It penetrates synovial fluid where concentrations may persist even when plasma concentrations fall. The terminal half­life is about 1 to 2 hours. Diclofenac acts by inhibiting cyclooxygenase, thus prevents the formation of prostaglandins, the mediators of inflammation. It also inhibits lipoxygenase thus preventing the synthesis of leukotrienes. Thus it acts on both the pathways and is a very potent anti­inflammatory drug/ medicine.

Paracetamol is an effective analgesic­antipyretic (relieves mild to moderate pain) and a weak anti­inflammatory agent. Paracetamol reduces fever by a direct action on the heat regulating centres to increase the dissipation of heat. It is readily absorbed from the g.i. tract with peak plasma concentrations occurring about 10 to 60 min. after oral administration. It is distributed into most body tissues.

Chlorzoxazone is a centrally ­acting agent for painful musculoskeletal conditions. It acts primarily at the level of the spinal cord and sub cortical areas of the brain where it inhibits multi synaptic reflex arcs involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles. Blood levels of chlorzoxazone can be detected in people during the first 30 min. and peak levels may be reached, in about 1 to 2 hours after oral administration.

ADVERSE EFFECTS:

• DICSAL-MR is well tolerated.
• Drowsiness, dizziness, light­ headedness, malaise, or overstimulation may be noted by an occasional patient.
• Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone.
• Pregnancy & Lactation ­ Not recommended in pregnant and lactating women.

CONTRAINDICATION:

• Contraindicated in patients with known hypersensitivity to any of the ingredients.

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Anti-inflammatory painkillers like etoricoxib are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just 'anti-inflammatories'. Etoricoxib eases pain and swelling (inflammation) in conditions like osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, and it may also be used for short periods of time in gout.

Etoricoxib works by blocking the effect of a natural chemical called cyclo-oxygenase-2 (COX-2) enzyme. This enzyme helps to make other chemicals, called prostaglandins, in the body. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX-2 enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

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In Pain & Inflammation

Etogen-T4 Etoricoxib 60 mg + Thiocolchicoside 4 mg Tablets

Etoricoxib

• Selective COX-2 inhibitor
• Possesses analgesic and antipyretic prnperties
• Exhibits rapid onset ot actiun with in 15 minutes
• Rapidly relieves pain in arthritis
• Possesses favourable gastric satety profile compared to other NSAID’s
• Superior gastrointestinal tolerability compared with traditinnal NSAlD's
• Etoricoxib 30 mg qid. provides superior etticacy vs placebo and comparable
• clinical elticacy vs Ibuprofen 2400 mg (800 mg t.i.d.) for the treatment nt OA.

Thiocolchicoside

• Potent competitive antagonist of GABA function
• A muscle relaxant agent with anti-inflammatory and analgesic actions
• Relaxes certain muscles in the body and relieves the stittness, pain and
• discomfort caused by strains, sprains or other iniury to the muscles

Indications

• Osteoarthritis , Rheumatoid Arthritis , Acute Painlul Conditions
• Dosage 1-2 times a day or as directed by the Physician

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Anti-inflammatory painkillers like etoricoxib are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just ''anti-inflammatories''. Etoricoxib eases pain and swelling (inflammation) in conditions like osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, and it may also be used for short periods of time in gout.

Etoricoxib works by blocking the effect of a natural chemical called cyclo-oxygenase-2 (COX-2) enzyme. This enzyme helps to make other chemicals, called prostaglandins, in the body. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX-2 enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

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Etonox-600mg ER Tablet

Each tablet contains:

Etodolac 600 mg (SR)

Etodolac is approved to treat:

·       osteoarthritis (immediate and extended-release forms)

·       rheumatoid arthritis (immediate and extended-release forms)

·       juvenile rheumatoid arthritis (extended-release form)

·       short-term pain (immediate release form-We have Etonox-P)

How it works

This medication belongs to a Non Steroidal Anti-inflammatory Drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever. It acts anti-inflammatory by lowering levels of COX-2 prostaglandin, a hormone-like substance that usually causes inflammation.

Etodolac side effects 

The common side effects that occur with etodolac include:

·       nausea, vomiting

·       diarrhoea or constipation

·       stomach pain

·       dizziness

·       headache

Safety for use for pregnant or brest feeding women is not established

For seniors: People aged 65 years or older should use caution when taking this medication. Your kidneys may not work as well, which could make it harder to remove this drug from your body. This increases your risk of side effects. Your doctor may monitor your kidneys regularly.

For children: It isn’t known if the immediate-release form of this medication is safe or effective in people younger than 18 years. It isn’t known if the extended-release form of this medication is safe or effective in people younger than 6 years.

Dosage for osteoarthritis 

Adult dosage (ages 18 years and older)

Typical dosage for long-term use:

o   The dose is 600 mg (SR) per day.

Dosage for rheumatoid arthritis

Adult dosage (ages 18 years and older)

o   The dose is 600 mg (SR) per day.

Child dosage (ages 0 to 17 years)

Dosage for people younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you. This information is only a guide line for marketing professionals and is insufficient for Medical Practioners to prescribe.